Construction of functional artificial kinetochore beads in cells Artificial kinetochore beads establish a biorientation-like state in the spindle Kohei Asai, Yuanzhuo Zhou, Osamu Takenouchi, Tomoya S Kitajima Science. 2024 Sep 20;385(6715):1366-1375 The kinetochore is a macromolecular complex built on centromeric DNA of chromosomes. It plays an essential role in chromosome segregation by mediating the dynamic...Read More
Discovery of mechanisms underlying chromosome abnormality in early embryos. Embryonic genome instability upon DNA replication timing program emergence Saori Takahashi, Hirohisa Kyogoku, Takuya Hayakawa, Hisashi Miura, Asami Oji, Yoshiko Kondo, Shin-ichiro Takebayashi, Tomoya S. Kitajima, Ichiro Hiratani Nature. 2024 Sep;633(8030):686-694. In collaboration with the Hiratani team at RIKEN BDR and Dr. Kyogoku at Kobe Univ,...Read More
Aging-associated reduction of chromosomal histones in mammalian oocytes Masashi Mori, Manami Koshiguchi, Osamu Takenouchi, Mei A. Mukose, Hinako M. Takase, Tappei Mishina, Hailiang Mei, Miho Kihara, Takaya Abe, Azusa Inoue, Tomoya S. Kitajima Genes to Cells. 2024. Online ahead of print. Our study using mouse oocytes revealed that chromosomal histones reduce with age. This aging-associated...Read More
Discovery of chromosome size-based spatial pathway to meiotic errors in oocytes. Live chromosome identifying and tracking reveals size-based spatial pathway of meiotic errors in oocytesOsamu Takenouchi, Yogo Sakakibara, Tomoya S. KitajimaScience. 2024 Jul 19;385(6706) Smaller chromosomes are more frequently mis-segregated in aged oocytes, but the underlying processes were unknown. We developed an imaging technique to...Read More
ChIP-Atlas 3.0: a data-mining suite to explore chromosome architecture together with large-scale regulome data Zhaonan Zou, Tazro Ohta, Shinya Oki Nucleic Acids Research 2024 May 16;gkae358 The regulation of gene expression in eukaryotes is precisely orchestrated in a spatiotemporal manner by cell-specific epigenomic states, genome-protein interactions, and histone modification patterns. To elucidate these regulatory mechanisms,...Read More
Dr. Hayashi’s paper has been published in EMBO Reports. Nutritional and metabolic control of germ cell fate through O-GlcNAc regulation Yohei Hayashi, Yukiko Tando, Yumi Ito-Matsuoka, Kaho Ikuta, Asuka Takehara, Katsutaro Morino, Hiroshi Maegawa, Yasuhisa Matsui EMBO Reports (2023)e56845 Fate determination of primordial germ cells (PGCs) is regulated in a multi-layered manner, involving signaling pathways,...Read More
Dr. Oki’s paper has been published in Epigenetics & Chromatin. Elucidating disease-associated mechanisms triggered by pollutants via the epigenetic landscape using large-scale ChIP-Seq data Zhaonan Zou, Yuka Yoshimura, Yoshihiro Yamanishi, Shinya Oki Epigenetics & Chromatin 2023 Sep 25;16:34 Despite well-documented effects on human health, the action modes of environmental pollutants are incompletely understood. Transcriptome-based approaches...Read More
Dr. Watanabe’s paper has been published in Stem Cell Reports. mRNA-based generation of marmoset PGCLCs capable of differentiation into gonocyte-like cells Musashi Kubiura-Ichimaru, Christopher Penfold, Kazuaki Kojima, Constance Dollet, Haruka Yabukami, Katsunori Semi, Yasuhiro Takashima, Thorsten Boroviak, Hideya Kawaji, Knut Woltjen, Aki Minoda, Erika Sasaki, Toshiaki Watanabe Stem Cell Reports. 2023 Aug 24;S2213-6711(23)00305-3 Primate germ...Read More
Dr.Kawamura’s paper has been published in EMBO J. Cellular senescence induction leads to progressive cell death via the INK4a-RB pathway in naked mole-rats Yoshimi Kawamura, Kaori Oka, Takashi Semba, Mayuko Takamori, Yuki Sugiura, Riyo Yamasaki, Yusuke Suzuki, Takeshi Chujo, Mari Nagase, Yuki Oiwa, Shusuke Fujioka, Sayuri Homma, Yuki Yamamura, Shingo Miyawaki, Minoru Narita, Takaichi Fukuda,...Read More
Dr.Inoue’s paper has been published in Sci. Rep. Derivation of embryonic stem cells from wild-derived mouse strains by nuclear transfer using peripheral blood cells Naomi Watanabe, Michiko Hirose, Ayumi Hasegawa, Keiji Mochida, Atsuo Ogura, Kimiko Inoue Sci Rep 2023 Jul 10;13(1):11175 Wild-derived mouse strains have been extensively used in biomedical research because of the high level...Read More
