Discovery of mechanisms underlying chromosome abnormality in early embryos.
Embryonic genome instability upon DNA replication timing program emergence
Saori Takahashi, Hirohisa Kyogoku, Takuya Hayakawa, Hisashi Miura, Asami Oji, Yoshiko Kondo, Shin-ichiro Takebayashi, Tomoya S. Kitajima, Ichiro Hiratani
Nature. 2024 Sep;633(8030):686-694.
In collaboration with the Hiratani team at RIKEN BDR and Dr. Kyogoku at Kobe Univ, Kitajima team discovered a mechanism of frequent chromosome abnormality in early mouse embryos. We found that chromosome segregation errors frequently occur at the 4- to 8-cell division, and that these errors are due to a stress caused by developmental stage-specific switch of DNA replication programs. Manipulating DNA replication speed may suppress chromosome abnormality in early embryos.
