Aging-associated reduction of chromosomal histones in mammalian oocytes
Masashi Mori, Manami Koshiguchi, Osamu Takenouchi, Mei A. Mukose, Hinako M. Takase, Tappei Mishina, Hailiang Mei, Miho Kihara, Takaya Abe, Azusa Inoue, Tomoya S. Kitajima
Genes to Cells. 2024. Online ahead of print.
Our study using mouse oocytes revealed that chromosomal histones reduce with age. This aging-associated histone reduction is likely independent of defects causing egg aneuploidy during the normal reproductive lifespan of mice.
