Spatial challenges of chromosomes in eggs.
Kif11-haploinsufficient oocytes reveal spatially differential requirements for chromosome biorientation
Tappei Mishina, Aurélien Courtois, Shuhei Yoshida, Kohei Asai, Hiroshi Kiyonari, Tomoya S Kitajima
EMBO Rep. 2025
Chromosome segregation requires spindle bipolarization and chromosome biorientation. In this paper, using mouse oocytes as a model, we show that the haploinsufficiency of the antiparallel microtubule motor KIF11 causes incomplete spindle bipolarization. Chromosomes in the outer region of the metaphase plate require more KIF11 to achieve biorientation. This study may contribute to the understanding and prediction of infertility.
