Kinetochores regulate timely spindle bipolarization for correct chromosome segregation in mouse oocytes.
MPS1 promotes timely spindle bipolarization to prevent kinetochore-microtubule attachment errors in oocytes
Shuhei Yoshida, Reiko Nakagawa, Kohei Asai, Tomoya S Kitajima
EMBO J. 2025
Spindle bipolarization and kinetochore-microtubule attachments are critical for chromosome segregation. We found that the MPS1 kinase regulates spindle bipolarization during meiosis I in mouse oocytes. The MPS1 kinase promotes spindle bipolarization prior to stabilization of kinetochore-microtubule attachment. Timely spindle bipolarization, which is regulated by kinetochores, suppresses the formation of incorrect kinetochore-microtubule attachments during meiosis I in mouse oocytes.
DOI : 10.1038/s44318-025-00461-w
