Discovery of mechanisms underlying chromosome abnormality in early embryos. Embryonic genome instability upon DNA replication timing program emergence Saori Takahashi, Hirohisa Kyogoku, Takuya Hayakawa, Hisashi Miura, Asami Oji, Yoshiko Kondo, Shin-ichiro Takebayashi, Tomoya S. Kitajima, Ichiro Hiratani Nature. 2024 Sep;633(8030):686-694. In collaboration with the Hiratani team at RIKEN BDR and Dr. Kyogoku at Kobe Univ,...Read More

Aging-associated reduction of chromosomal histones in mammalian oocytes Masashi Mori, Manami Koshiguchi, Osamu Takenouchi, Mei A. Mukose, Hinako M. Takase, Tappei Mishina, Hailiang Mei, Miho Kihara, Takaya Abe, Azusa Inoue, Tomoya S. Kitajima Genes to Cells. 2024. Online ahead of print. Our study using mouse oocytes revealed that chromosomal histones reduce with age. This aging-associated...Read More